Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice
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Antidepressant-like effect of Valeriana glechomifolia Meyer (Valerianaceae) in mice
The antidepressant-like effect of a supercritical CO2 (SCCO2) Valeriana glechomifolia extract enriched in valepotriates was investigated in a mice tail suspension test (TST) and forced swimming test (FST). The SCCO2 extract decreased mice immobility in the FST (0.5-20 mg/kg p.o.) and elicited a biphasic dose-response relationship in the TST (1-20 mg/kg p.o.) with no alterations in locomotor act...
متن کاملConstituents of Valeriana glechomifolia Meyer.
Valeriana glechomifolia Meyer is a small herb 5}10 cm high, growing in South Brazil. The plant was collected in April, 1998 in Sa8 o JoseH dos Ausentes, RS, Brazil and identi"ed by M. Sobral (Curso de PoH s-Graduac7 a8 o em Cie( ncias Farmace( uticas da Universidade Federal do Rio Grande do Sul, Brazil). Voucher specimens (M. Sobral, 7733) are kept in the Herbarium of the Universidade Federal d...
متن کاملDiene Valepotriates from Valeriana glechomifolia Prevent Lipopolysaccharide-Induced Sickness and Depressive-Like Behavior in Mice
Valeriana glechomifolia, a native species from southern Brazil, presents antidepressant-like activity and diene valepotriates (VAL) contribute to the pharmacological properties of the genus. It is known that depression can develop on an inflammation background in vulnerable patients and antidepressants present anti-inflammatory properties. We investigated the effects of VAL (10 mg/kg, p.o.) on ...
متن کاملAntidepressant-like effect of aqueous extract from Rosa damascena in mice
Objective: Rosa damascena mill L (R. damascena) is an ornamental plant that has several therapeutic (such as sedative and hypnotic) effects. It also heals depression, grief, nervous stress and tension. In the present study we evaluated antidepressant-like effect of R. damascena using forced swimming test (FST). Material and Methods: Three doses of aqueous extract (15, 60 and 90 mg/kg) was inje...
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Background: In some disorders such as diabetes mellitus patients can display depressive symptoms. Metformin is among the first-line treatments for management of the type 2 diabetes mellitus which may have some anti-depressant effect. Objective: Current investigation was performed to examine the anti-depressant effects of metformin and the involvement of nitric oxide (NO) in this way, in an expe...
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ژورنال
عنوان ژورنال: Progress in Neuro-Psychopharmacology and Biological Psychiatry
سال: 2012
ISSN: 0278-5846
DOI: 10.1016/j.pnpbp.2011.08.015